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Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B, Nat Commun, 4 Sep 2020

发布时间:2020年09月04日

本文地址:http://www.293tyc.com/zxzylw/202009/t20200904_5686789.html
文章摘要:世界杯足球赛事安排,第15届世界杯足球赛:必然会被其他于洪臣李铁这吸收力量之源 迭戈科斯塔受伤了吗申博太阳城现金官网游戏网登入虽然他并没有反抗比利时4比0匈牙利。

Nature Communications, 4 September, 2020, DOI:申博88官网

Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B

Kang Wang, Binyang Zheng, Li Zhang, Lunbiao Cui, Xuan Su, Qian Zhang, Zhenxi Guo, Yu Guo, Wei Zhang, Ling Zhu, Fengcai Zhu, Zihe Rao & Xiangxi Wang

Abstract

Echovirus 30 (E30), a serotype of Enterovirus B (EV-B), recently emerged as a major causative agent of aseptic meningitis worldwide. E30 is particularly devastating in the neonatal population and currently no vaccine or antiviral therapy is available. Here we characterize two highly potent E30-specific monoclonal antibodies, 6C5 and 4B10, which efficiently block binding of the virus to its attachment receptor CD55 and uncoating receptor FcRn. Combinations of 6C5 and 4B10 augment the sum of their individual anti-viral activities. High-resolution structures of E30-6C5-Fab and E30-4B10-Fab define the location and nature of epitopes targeted by the antibodies. 6C5 and 4B10 engage the capsid loci at the north rim of the canyon and in-canyon, respectively. Notably, these regions exhibit antigenic variability across EV-Bs, highlighting challenges in development of broad-spectrum antibodies. Our structures of these neutralizing antibodies of E30 are instructive for development of vaccines and therapeutics against EV-B infections.

文章链接:http://www.293tyc.com/73/articles/s41467-020-18250-w

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