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A single-cell transcriptome atlas of the aging human and macaque retina, Natl Sci Rev, 26 Aug 2020

发布时间:2020年08月26日

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National Science Review, 26 August, 2020, DOI:申博88官网

A single-cell transcriptome atlas of the aging human and macaque retina

Wenyang Yi, Yufeng Lu, Suijuan Zhong, Mei Zhang, Le Sun, Hao Dong, Mengdi Wang, Min Wei, Haohuan Xie, Hongqiang Qu, Rongmei Peng, Jing Hong, Ziqin Yao, Yunyun Tong, Wei Wang, Qiang Ma, Zeyuan Liu, Yuqian Ma, Shouzhen Li, Chonghai Yin, Jianwei Liu, Chao Ma, Xiaoqun Wang*, Qian Wu*, Tian Xue*

Abstract

The human retina is a complex neural tissue that detects light and sends visual information to the brain. However, the molecular and cellular processes that underlie aging primate retina remain unclear. Here, we provide a comprehensive transcriptomic atlas based on 119,520 single cells of the foveal and peripheral retina of humans and macaques covering different ages. The molecular features of retinal cells differed between the two species, suggesting the distinct regional and species specializations of the human and macaque retinae. In addition, human retinal aging occurred in a region- and cell-type- specific manner. Aging of human retina exhibited a foveal to peripheral gradient. MYO9A? rods and a horizontal cell subtype were greatly reduced in aging retina, indicating their vulnerability to aging. Moreover, we generated a dataset showing the cell-type- and region- specific gene expression associated with 55 types of human retinal disease, which provides a foundation to understand the molecular and cellular mechanisms underlying human retinal diseases. Together, these datasets are valuable for understanding the molecular characteristics of primate retina, as well as the molecular regulation of aging progression and related diseases.

文章链接:http://www.46q.22mcp.com/nsr/advance-article/doi/10.1093/nsr/nwaa179/5896967?guestAccessKey=a5362662-388a-4d1d-a7c9-fade8dbdeb74

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